PEGS Boston 2026: Design Is the Easy Part Now
Five days at PEGS Boston. The design question is mostly answered. The hard problems have moved to CMC tolerance and immune acceptance, and the field knows it.
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Science
Nanobodies From a Laptop, BCRs From a Model, and a Mutation-Agnostic Bet
Three signals this month, all pointing at the same thing: antibody discovery is becoming a computational discipline first and a wet-lab one second.
Nanobodies in silico, rabbits in wet lab, and a mutation-agnostic antibody that skips the JAK2 debate
Antibody discovery is splitting into two cultures. One trusts the model. The other trusts the rabbit. Both had a good month.
VHH Humanization Is Mostly a Search Problem, Not a Grafting Problem
Everyone frames nanobody humanization as CDR grafting. It's not. It's a search problem with a brutal fitness landscape.